LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway
LMK235 attenuates chronic inflammation and fibrosis post-MI, leading to improved cardiac function. The anti-inflammatory effect of LMK235 may result from inhibition of the LSD1-NF-κB pathway in macrophages. The antifibrotic effect of LMK235 may result from inhibition of the LSD1-Smad2/3 pathway in cardiac fibroblasts.
Authors
- Jiafeng Lin (ORCID: https://orcid.org/0000-0003-1748-7794)
- Laidi Xie
- Fang-Zhou Lv
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1038/s41598-024-74887-3
- Citations
- 5
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Natural Science Foundation of Zhejiang Province