Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers
This study indicates that a dose of 2 g cefiderocol achieves concentrations in plasma considered sufficient for treating relevant bacterial species. Assuming a comparable PK/PD target for soft tissues, sufficiently high concentrations would also be achieved in soft tissues.
Authors
- Michael Wölf-Duchek
- Anselm Jorda (ORCID: https://orcid.org/0000-0001-5500-5878)
- Christoph Dorn (ORCID: https://orcid.org/0000-0002-2560-9598)
- Iris K. Minichmayr (ORCID: https://orcid.org/0000-0002-2679-8589)
- Markus Zeitlinger (ORCID: https://orcid.org/0000-0002-1873-3953)
- Wisse van Os (ORCID: https://orcid.org/0000-0003-1709-4173)
- J. G. Coen van Hasselt (ORCID: https://orcid.org/0000-0002-1664-7314)
- Felix Bergmann (ORCID: https://orcid.org/0000-0002-1224-9036)
- Valentin al Jalali (ORCID: https://orcid.org/0000-0002-9196-1936)
- Maria Sanz-Codina (ORCID: https://orcid.org/0000-0002-1687-5296)
- Anh Duc Pham (ORCID: https://orcid.org/0000-0002-0279-1761)
- Edith Lackner
- Constantin Lier
Institutions
- Leiden University (NL)
- Centre for Human Drug Research (NL)
- University of Regensburg (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1093/jac/dkae359
- Citations
- 7
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- Shionogi