Nodule-Specific NRF2-Targeted Upregulation in Patients With <i>KEAP1</i> Mutations and Familial Nontoxic Multinodular Goiter
KEAP1 germline heterozygous mutations exert excessive NRF2 activity in the thyroid gland and may confer cytoprotective effects even under abundant reactive oxygen species associated with thyroid hormone production, resulting in thyroid hyperplasia with scarce degradation.
Authors
- Akira Miyauchi (ORCID: https://orcid.org/0000-0003-0041-197X)
- Norisato Mitsutake (ORCID: https://orcid.org/0000-0002-2744-8046)
- Eijun Nishihara (ORCID: https://orcid.org/0000-0003-1786-0077)
- Miyoko Higuchi (ORCID: https://orcid.org/0000-0001-8262-2652)
- Shuji Fukata (ORCID: https://orcid.org/0000-0001-6816-0228)
- Mitsuyoshi Hirokawa (ORCID: https://orcid.org/0000-0001-5558-7142)
- Takahiko Kogai (ORCID: https://orcid.org/0000-0002-2413-2564)
- Takashi Akamizu (ORCID: https://orcid.org/0000-0003-4960-8271)
- Akira Hishinuma (ORCID: https://orcid.org/0000-0002-0703-679X)
- Michiko Matsuse (ORCID: https://orcid.org/0000-0001-6178-3342)
- Mitsushige Nishikawa (ORCID: https://orcid.org/0009-0007-6307-3425)
- Ito M (ORCID: https://orcid.org/0000-0002-2578-5786)
- Yuka Ito
Institutions
- Kuma Hospital (JP)
- Nagasaki University (JP)
- Dokkyo Medical University (JP)
- Center for Excellence in Education (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1210/clinem/dgae699
- Citations
- 3
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.70