Harnessing the power of AI in precision medicine: NGS-based therapeutic insights for colorectal cancer cohort
Our study highlights three distinct approaches for identifying potential therapeutic targets in cancer patients. Each approach yielded valuable insights into our cohort, underscoring the relevance and utility of these methodologies in the development of precision and personalized cancer therapies. Importantly, we developed a novel AI model that aligns tumors with representative cell lines using RNAseq and methylation data. This model enables us to identify cell lines closely resembling patient tumors, facilitating accurate selection of models needed for in vitro validation.
Authors
- Michał Warchoł
- Weronika Czarnocka (ORCID: https://orcid.org/0000-0003-4062-0370)
- Martyna Balawejder (ORCID: https://orcid.org/0009-0003-9299-1584)
- Anna Sanecka-Duin (ORCID: https://orcid.org/0000-0001-7684-2149)
- Maciej Jasiński (ORCID: https://orcid.org/0000-0001-5416-6127)
- Joanna Marczyńska-Grzelak
- Agnieszka Blum (ORCID: https://orcid.org/0009-0008-3096-5440)
- Mirosław Szura (ORCID: https://orcid.org/0000-0002-9993-7471)
- Piotr Skoczylas
- Joanna Welanyk (ORCID: https://orcid.org/0009-0004-5137-0068)
- Marek Karczewski (ORCID: https://orcid.org/0000-0002-9642-0709)
- Rafał Szatanek (ORCID: https://orcid.org/0000-0003-1327-6092)
- Zofia Orzeszko (ORCID: https://orcid.org/0000-0001-6805-1996)
- Bartłomiej Król-Józaga (ORCID: https://orcid.org/0000-0003-2526-0629)
- Grzegorz Torbicz (ORCID: https://orcid.org/0000-0002-4670-8798)
- Stanisław Kłęk (ORCID: https://orcid.org/0000-0002-7887-3464)
- Giovanni Mazzocco (ORCID: https://orcid.org/0009-0001-8644-5179)
- Łukasz Wohadło (ORCID: https://orcid.org/0009-0003-7198-4465)
- Marek J. Piatek
- Oskar Gniewek (ORCID: https://orcid.org/0009-0009-8696-812X)
- Łukasz Grochowalski (ORCID: https://orcid.org/0000-0001-8348-1695)
- Michał Wysocki (ORCID: https://orcid.org/0000-0002-2468-1117)
- Beata Markowska (ORCID: https://orcid.org/0000-0002-0380-6777)
- Victor Murcia Pienkowski (ORCID: https://orcid.org/0000-0002-1383-8019)
- Maciej Borys (ORCID: https://orcid.org/0000-0003-4605-113X)
- Paweł Biernat (ORCID: https://orcid.org/0000-0002-5308-4426)
- Tomasz Kucharczyk (ORCID: https://orcid.org/0009-0005-0953-4265)
- Małgorzata Kamuda
- Jan Kaczmarczyk (ORCID: https://orcid.org/0000-0002-8957-8487)
- Jakub Widawski
- Agata Zaremba
Institutions
- Poznan University of Medical Sciences (PL)
- Jagiellonian University (PL)
- Holy Cross University (PL)
- Andrzej Frycz Modrzewski Krakow University (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fonc.2024.1407465
- Citations
- 3
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.21