Quercetin Attenuates MRGPRX2-Mediated Mast Cell Degranulation via the MyD88/IKK/NF-κB and PI3K/AKT/ Rac1/Cdc42 Pathway
Quercetin is a promising treatment for allergic diseases by acting as a CLM-1 agonist that inhibits MRGPRX2-mediated mast cell degranulation.
Authors
- Chenrui Zhao
- Yihan Huang
- Tao Zhang (ORCID: https://orcid.org/0000-0002-5607-4610)
- Yuanyuan Ding (ORCID: https://orcid.org/0000-0001-7588-2181)
- Bin Guo
- Chao Wang (ORCID: https://orcid.org/0000-0001-7885-9673)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/jir.s480644
- Citations
- 13
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation