Aronia melanocarpa L. fruit peels show anti-cancer effects in preclinical models of breast carcinoma: The perspectives in the chemoprevention and therapy modulation
This study is the first to analyze the antitumor effect of <i>A. melanocarpa</i> in selected models of experimental breast carcinoma <i>in vivo</i> and <i>in vitro</i>. The utilization of the antitumor effects of aronia in clinical practice is still minimal and requires precise and long-term clinical evaluations. Individualized cancer-type profiling and patient stratification are crucial for effectively implementing plant nutraceuticals within targeted anti-cancer strategies in clinical oncology.
Authors
- Peter Kubatka (ORCID: https://orcid.org/0000-0003-4312-5076)
- Sandra Meršaková (ORCID: https://orcid.org/0000-0001-5273-4434)
- Jakub Treml (ORCID: https://orcid.org/0000-0002-8690-9981)
- Dietrich Büsselberg (ORCID: https://orcid.org/0000-0001-5196-3366)
- Dušan Braný (ORCID: https://orcid.org/0009-0009-4912-8754)
- Dominika Šebová (ORCID: https://orcid.org/0000-0002-2109-1824)
- Marián Adamkov (ORCID: https://orcid.org/0000-0003-1044-2569)
- Martin Kello (ORCID: https://orcid.org/0000-0002-2454-5799)
- Emil Švajdlenka (ORCID: https://orcid.org/0000-0002-4876-6297)
- Ján Mojžíš (ORCID: https://orcid.org/0000-0002-7974-4525)
- Marek Samec (ORCID: https://orcid.org/0000-0002-2545-7694)
- Kamil Biringer (ORCID: https://orcid.org/0000-0002-3471-0508)
- Karol Kajo (ORCID: https://orcid.org/0000-0002-8178-1093)
- Karel Šmejkal (ORCID: https://orcid.org/0000-0002-4336-7924)
- Ján Strnádel (ORCID: https://orcid.org/0000-0002-7233-6537)
- Zora Lasabová (ORCID: https://orcid.org/0000-0003-2530-3991)
- Alena Mazuráková (ORCID: https://orcid.org/0000-0002-1111-0120)
- Lenka Lacková
- Dana Dvorská (ORCID: https://orcid.org/0009-0000-1080-6460)
Institutions
- University of Pavol Jozef Šafárik (SK)
- Masaryk University (CZ)
- Weill Cornell Medical College in Qatar (QA)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fonc.2024.1463656
- Citations
- 7
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Univerzita Komenského v Bratislave
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV