SMAD4 enhances the cytotoxic efficacy of human NK cells against colorectal cancer cells via the m6A reader YTHDF2
Our study unveils a novel mechanism through which SMAD4 modulates the cytotoxicity of NK cells towards CRC cells, suggesting that SMAD4 may hold promise as a potential therapeutic target for NK cell therapy in CRC.
Authors
- Lei Cai (ORCID: https://orcid.org/0000-0001-6241-6261)
- Xinxin Li (ORCID: https://orcid.org/0000-0001-6760-0957)
- Siyong Huang
- Yilin Wang
Institutions
- Northwestern Polytechnical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Xi’an International University (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1440308
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Natural Science Foundation of Shaanxi Province
- Basic and Applied Basic Research Foundation of Guangdong Province