Brugia malayi filarial helminth-derived extracellular vesicles suppress antigen presenting cell function and antigen-specific CD4+ T cell responses
Taken together, our data suggest a modulatory role of EVs on APC function that likely leads to defects in T cell effector function.
Authors
- Justin Lack (ORCID: https://orcid.org/0000-0003-0584-4010)
- Gayatri Sanku
- Paul Schaughency (ORCID: https://orcid.org/0000-0002-3358-2102)
- Thomas B. Nutman (ORCID: https://orcid.org/0000-0001-6887-4941)
- Neelam Redekar (ORCID: https://orcid.org/0000-0002-4819-9034)
- Pedro H. Gazzinelli-Guimaraes (ORCID: https://orcid.org/0000-0003-0669-1642)
- Alessandra Ricciardi (ORCID: https://orcid.org/0000-0002-5005-7879)
Institutions
- National Institutes of Health (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1436818
- Citations
- 3
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research