Case report: target antigen and subclass switch in a patient with autoimmune nodopathy
This case demonstrates that autoimmunity to (para)nodal structures can reoccur especially in patients prone to autoimmune disorders and can switch its target antigen and subclass in the course of disease. The presence of auto-antibodies against different targets at the node of Ranvier has direct implications for therapeutic management. We suggest a close follow-up of patients with AN after successful therapy. In case of deterioration despite seronegativity, non-specific tests such as teased fiber assays and repeated screening for different target antigens should be considered.
Authors
- Claudia Sommer (ORCID: https://orcid.org/0000-0002-7064-5002)
- Luise Appeltshauser (ORCID: https://orcid.org/0000-0001-5248-4009)
- Carmen Villmann (ORCID: https://orcid.org/0000-0003-1498-6950)
- Kathrin Doppler (ORCID: https://orcid.org/0000-0003-2883-0009)
- Helena Glenewinkel
- Sophia Rohrbacher
- Lena Wessely
Institutions
- Universitätsklinikum Würzburg (DE)
- Orthopädische Praxis (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fimmu.2024.1475478
- Citations
- 4
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Deutsche Forschungsgemeinschaft
- Julius-Maximilians-Universität Würzburg
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg