Androgen Deficiency, Associations and Survival of Men With Stage 4 and 5 Chronic Kidney Disease: A Cohort Study
AD is highly prevalent among this population, and increases further with older age and more severe CKD warranting haemodialysis. Association of lower Hb and higher ESA dose with lower T concentration might be causative, which has important pharmaco-economic as well as clinical implications. Lower survival in men with low T, more likely reflects overall poor health rather than causation. A properly constituted randomised controlled study evaluating the effect of native T replacement is warranted in men with CKD and AD.
Authors
- Timothy W. Shipley
- Nigel S. Kanagasundaram
- Richard Quinton (ORCID: https://orcid.org/0000-0002-4842-8095)
- Nipun Lakshitha de Silva (ORCID: https://orcid.org/0000-0002-4467-3659)
- Channa Nalin Jayasena (ORCID: https://orcid.org/0000-0002-2578-8223)
- Bruna Barbar (ORCID: https://orcid.org/0000-0003-3534-8165)
- Neomal De Silva (ORCID: https://orcid.org/0000-0003-3763-2020)
- Rohana J. Wright
- Chris Boot
Institutions
- NHS Lothian (GB)
- General Sir John Kotelawala Defence University (LK)
- Royal Victoria Infirmary (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Freeman Hospital (GB)
- Albyn Hospital (GB)
- St John's Hospital (GB)
- Imperial College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2024-10-06
- DOI
- https://doi.org/10.1111/cen.15146
- Citations
- 4
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Bayer, United Kingdom