Anti-platelet Effects of Artemisinin through Regulation of Cyclic Nucleotide on Collagen-induced human Platelets

The discovery of a novel substance capable of regulating or suppressing platelet aggregation holds significant promise for the prevention and treatment of cardiovascular diseases.Artemisinin, a compound derived from plants like Artemisia or Scopolia, has demonstrated potential across various fields, including anticancer and Alzheimer's disease research.However, its specific role and mechanisms in influencing platelet activation and thrombus formation remain incompletely understood.This study delves into elucidating how artemisinin affects platelet activation and thrombus formation.Results revealed a significant increase in cAMP production with varying doses of artemisinin, alongside notable phosphorylation of VASP and IP 3 R-both substrates for cAMP-dependent kinase.This phosphorylation led to the inhibition of Ca 2+ mobilization from the dense tubular system, consequently reducing platelet activity via IIb/ 3 inactivation and suppressing fibrinogen binding.Furthermore, artemisinin exhibited inhibition of thrombin-induced thrombus formation.These findings suggest that artemisinin holds promise as an effective prophylactic and therapeutic agent against cardiovascular diseases, specifically targeting abnormal platelet activation and thrombus formation.