Photoredox/Copper-Cocatalyzed Domino Annulation of Oxime Esters and NH<sub>4</sub>SCN: Access to Fully Substituted 2-Aminothiazoles
Domino cyclization of oxime esters and NH<sub>4</sub>SCN facilitated by photoredox and copper cocatalysis has been established. Various structurally diverse fully substituted 2-aminothiazoles have been obtained in good yields at room temperature. It is featured by mild conditions, favorable functional group tolerance, and wide substrate scope. The present reaction is amenable to gram-scale synthesis, which is expected to find potential applications in organic synthesis and drug discovery. A plausible reaction mechanism is proposed.
Authors
- Shujun Cao
- Yichao Wan (ORCID: https://orcid.org/0000-0003-1457-733X)
- Yong-Yan Luo
- Yanyan Zhang (ORCID: https://orcid.org/0000-0002-2827-8042)
- Mengting Liu (ORCID: https://orcid.org/0000-0003-4972-9006)
- Xiaozhen Wang (ORCID: https://orcid.org/0000-0003-0612-3469)
Institutions
- Hunan University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1021/acs.joc.4c01951
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Science and Technology Program of Hunan Province