Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study
The indicated mechanisms of action of diacerein/rhein can reduce viral replication and mitigate the inflammatory response related to SARS-CoV-2. These findings are preliminary and require confirmation in clinical trials.
Authors
- Isabella Bonilha (ORCID: https://orcid.org/0000-0002-5581-5763)
- Victor Corasolla Carregari (ORCID: https://orcid.org/0000-0001-6863-1333)
- Wilson Nadruz (ORCID: https://orcid.org/0000-0002-0003-5102)
- Lı́cio A. Velloso (ORCID: https://orcid.org/0000-0002-4806-7218)
- Sean M. Davidson (ORCID: https://orcid.org/0000-0001-5182-4980)
- Flávia Elisa Galdino (ORCID: https://orcid.org/0000-0002-7799-3077)
- Deepak L. Bhatt (ORCID: https://orcid.org/0000-0002-1278-6245)
- Marcelo A. Mori
- Watson Loh (ORCID: https://orcid.org/0000-0002-8049-3321)
- Joseane Morari (ORCID: https://orcid.org/0000-0002-0728-4283)
- Helison Rafael Pereira do Carmo (ORCID: https://orcid.org/0000-0003-0608-8640)
- Alessandro S. Farias (ORCID: https://orcid.org/0000-0001-6759-1819)
- Daniel Martins‐de‐Souza (ORCID: https://orcid.org/0000-0003-3595-5846)
- Gustavo Gastão Davanzo (ORCID: https://orcid.org/0000-0002-6723-1933)
- Pedro Gonçalves de Oliveira (ORCID: https://orcid.org/0000-0001-9853-0031)
- José Luiz Proença‐Módena (ORCID: https://orcid.org/0000-0002-4996-3153)
- Stéfanie Primon Muraro (ORCID: https://orcid.org/0000-0002-5105-6659)
- Filipe A. Moura (ORCID: https://orcid.org/0000-0001-8017-1675)
- Lauar de Brito Monteiro (ORCID: https://orcid.org/0000-0003-1258-6857)
- Pedro M. Moraes‐Vieira (ORCID: https://orcid.org/0000-0002-8263-786X)
- Natália S. Brunetti (ORCID: https://orcid.org/0000-0003-2803-3763)
- Andrei C. Spósito (ORCID: https://orcid.org/0000-0001-7127-2052)
- Gabriela Fabiano de Souza (ORCID: https://orcid.org/0000-0001-7285-0790)
- Derek M. Yellon (ORCID: https://orcid.org/0000-0001-7791-9320)
- Guilherme Reis-de-Oliveira
- Joaquim Barreto
- Erica I. L. Gomes
- Alejandro Rossel Castillo
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Mount Sinai Hospital (US)
- D’Or Institute for Research and Education (BR)
- Brazilian Synchrotron Light Laboratory (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Brazilian Center for Research in Energy and Materials (BR)
- Thrombolysis in Myocardial Infarction Study Group (US)
- University College London (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fphar.2024.1402032
- Citations
- 4
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual de Campinas