Spike and nucleocapsid antibody dynamics following <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection and vaccination: Implications for sourcing <scp>COVID</scp>‐19 convalescent plasma from routinely collected blood donations
Routine plasma donations from donors with hybrid immunity had high S bAb and potent neutralizing activity for 3-6 months after infection. In donations with high (>4000 BAU/mL) S IgG, >95% had high nAb titers (>500) against ancestral and variant S, regardless of COVID-19 symptoms. These findings provide the basis for test-based criteria for qualifying CCP from routine blood donations.
Authors
- Jefferson M. Jones (ORCID: https://orcid.org/0000-0003-4974-9058)
- Valerie Green (ORCID: https://orcid.org/0000-0002-7101-3111)
- Steven H Kleinman (ORCID: https://orcid.org/0000-0002-1638-2969)
- Brad J. Biggerstaff (ORCID: https://orcid.org/0000-0002-3105-3530)
- David J. Wright (ORCID: https://orcid.org/0000-0001-8666-4155)
- Eduard Grebe (ORCID: https://orcid.org/0000-0001-7046-7245)
- Paul Contestable
- Paula Saá (ORCID: https://orcid.org/0000-0001-6077-4532)
- Bryan R. Spencer (ORCID: https://orcid.org/0000-0002-9008-9154)
- Mars Stone (ORCID: https://orcid.org/0000-0001-5619-2767)
- Elaine A. Yu (ORCID: https://orcid.org/0000-0003-2433-9562)
- Michael Paul Busch (ORCID: https://orcid.org/0000-0002-1446-125X)
- Clara Di Germanio (ORCID: https://orcid.org/0000-0002-6047-211X)
- Marion C. Lanteri (ORCID: https://orcid.org/0000-0002-4213-5013)
- Graham Simmons (ORCID: https://orcid.org/0000-0002-9615-7023)
- Brendan G. Balasko
- Xutao Deng (ORCID: https://orcid.org/0000-0002-7372-3758)
- Isaac Lartey
- Rachel Martinelli
Institutions
- Centers for Disease Control and Prevention (US)
- Westat (United States) (US)
- American Red Cross (US)
- University of British Columbia (CA)
- University of California, San Francisco (US)
- Pacific Research Institute (US)
- Vitalant (US)
- Ortho Clinical Diagnostics (United States) (US)
Publication Details
- Journal
- Transfusion
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1111/trf.18017
- Citations
- 9
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Centers for Disease Control and Prevention