Exploiting phenotypic heterogeneity to improve production of glutathione by yeast
The results corroborate that the system developed here improves GSH production by targeting low-producing cells. This supports the potential for exploiting end-product/promoter interactions to enrich high-producing cells in phenotypically heterogeneous populations, in order to improve metabolite production by yeast.
Authors
- Klaus Winzer (ORCID: https://orcid.org/0000-0002-3956-8096)
- Cindy Vallières (ORCID: https://orcid.org/0000-0001-6409-1296)
- Chris Finnis
- Simon V. Avery (ORCID: https://orcid.org/0000-0002-2102-2255)
- Mingzhi Xu (ORCID: https://orcid.org/0000-0001-6823-7571)
Institutions
- University of Nottingham (GB)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s12934-024-02536-5
- Citations
- 5
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council