Locus coeruleus co‐activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study
Dissociative seizures often arise during high affective arousal. The locus coeruleus is a brain structure involved in managing such acute arousal states. We investigated whether the activity of the locus coeruleus correlates with activity in other regions of the brain (which we refer to as "brain states"), and whether those brain states were different between patients with dissociative seizures and healthy controls. We found that patients tended to stay in certain locus coeruleus-dependent brain states instead of switching between them. This might be related to the loss of awareness and disruptions of brain functions ("dissociation") that patients experience during seizures.
Authors
- Johannes Jungilligens (ORCID: https://orcid.org/0000-0002-4846-8337)
- Samantha Weber (ORCID: https://orcid.org/0000-0002-2689-2938)
- Selma Aybek (ORCID: https://orcid.org/0000-0002-7877-6760)
- Stoyan Popkirov (ORCID: https://orcid.org/0000-0001-6168-0036)
Institutions
- University of Bern (CH)
- University of Fribourg (CH)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Hospital of Zurich (CH)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Essen University Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1002/epi4.13050
- Citations
- 7
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung