Ag(I)-Mediated Site-Selective C(sp<sup>2</sup>)-H Chalcogenation of Tryptophan-Peptides with Dichalcogenides at Room Temperature
This report presents a silver-mediated site-selective chalcogenation of tryptophan-containing peptides with various dichalcogenides (disulfides/diselenides) at room temperature in good to excellent yields. The significant features include broad substrate scope, functional group diversity, late-stage modification of drug molecules (Dopamine and Levodopa), and various valuable postsynthetic transformations under mild conditions.
Authors
- Raghunath Bag
- Nagendra K. Sharma (ORCID: https://orcid.org/0000-0003-0901-0523)
- Malobika Kar (ORCID: https://orcid.org/0000-0002-5859-8821)
Institutions
- National Institute of Science Education and Research (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1021/acs.joc.4c01730
- Citations
- 8
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Department of Atomic Energy, Government of India
- Science and Engineering Research Board