APC mutations dysregulate alternative polyadenylation in cancer
As APC has been previously identified as an RNA-binding protein that preferentially binds 3' UTRs during mouse neurogenesis, our results suggest that APC promotes proximal poly(A) site use and that APC loss and altered expression contribute to pervasive APA dysregulation in cancers.
Authors
- Austin M. Gabel (ORCID: https://orcid.org/0000-0002-1418-0327)
- Andrea E. Belleville (ORCID: https://orcid.org/0000-0001-9549-4338)
- Robert K. Bradley (ORCID: https://orcid.org/0000-0002-8046-1063)
- Jose Mario Bello Pineda (ORCID: https://orcid.org/0000-0003-1417-9200)
- James D. Thomas (ORCID: https://orcid.org/0000-0002-8893-6350)
Institutions
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Genome biology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s13059-024-03406-4
- Citations
- 5
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.17