Analysis of bleeding outcomes in patients with hypoproliferative thrombocytopenia in the A‐<scp>TREAT</scp> clinical trial
The overall rate of WHO grade 2+ bleeding was similar to previous reports, albeit with lower rates of gastrointestinal bleeding. Vaginal bleeding was common in participants of childbearing potential. Platelets ≤5000/μL remained a risk factor for bleeding. Regardless of platelet count, bleeding risk increased with HCT < 21%, suggesting a red blood cell transfusion threshold above 21% should be considered to mitigate bleeding. More investigation is needed on strategies to reduce bleeding in this population.
Authors
- Amy Sarah Ginsburg (ORCID: https://orcid.org/0000-0002-2291-2276)
- Heather Herren
- Darrell J. Triulzi
- Nigel S. Key (ORCID: https://orcid.org/0000-0002-8930-4304)
- Susanne May (ORCID: https://orcid.org/0000-0002-3601-7432)
- Nahed El Kassar
- Terry Gernsheimer (ORCID: https://orcid.org/0000-0002-2671-5608)
- Siobhan P. Brown (ORCID: https://orcid.org/0000-0002-4774-3122)
- Anton Ilich (ORCID: https://orcid.org/0000-0002-7669-0760)
- Jacqueline N. Poston (ORCID: https://orcid.org/0000-0003-2431-5106)
Institutions
- University of Vermont (US)
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- National Heart, Lung, and Blood Institute (US)
Publication Details
- Journal
- Transfusion
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1111/trf.18028
- Citations
- 2
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Heart, Lung, and Blood Institute