Targeting CXCR2 ameliorated tacrolimus-induced nephrotoxicity by alleviating overactivation of PI3K/AKT/mTOR pathway and calcium overload
The present study was firstly to report that CXCL2-CXCR2 activated PI3K/AKT/mTOR pathway and calcium overload in tacrolimus-induced nephrotoxicity, and targeting CXCR2 could inhibit the progression of tacrolimus-induced nephrotoxicity.
Authors
- Su‐Mei He
- Dongdong Wang (ORCID: https://orcid.org/0000-0002-6195-4428)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-6875-0025)
- Xiao Chen (ORCID: https://orcid.org/0000-0002-0386-3675)
- Ke Hu (ORCID: https://orcid.org/0000-0002-7883-369X)
Institutions
- Xuzhou Medical College (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1016/j.biopha.2024.117526
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52