Clinical Utility of Genetic Variants in <i>PNPLA3</i> and <i>TM6SF2</i> to Predict Liver‐Related Events in Metabolic Dysfunction‐Associated Steatotic Liver Disease
The approach of measuring the FIB-4 index first followed by assessment of genetic polymorphisms efficiently detected patients at high risk of developing LRE. Therefore, this two-step strategy could be used as a screening method in large populations of patients with MASLD.
Authors
- Atsushi Nakajima (ORCID: https://orcid.org/0000-0002-6263-1436)
- Yasuhide Mitsumoto (ORCID: https://orcid.org/0000-0002-1471-9062)
- Miwa Kawanaka (ORCID: https://orcid.org/0000-0003-2341-5199)
- Takeshi Okanoue (ORCID: https://orcid.org/0000-0002-2390-3400)
- Toshihide Shima (ORCID: https://orcid.org/0000-0002-4120-9121)
- Saiyu Tanaka
- Michihiro Iwaki (ORCID: https://orcid.org/0000-0002-7650-0699)
- Masato Yoneda (ORCID: https://orcid.org/0000-0001-7815-549X)
- Yoshito Itoh (ORCID: https://orcid.org/0000-0001-9890-3635)
- Yuya Seko (ORCID: https://orcid.org/0000-0002-3658-5894)
- Kanji Yamaguchi (ORCID: https://orcid.org/0000-0002-0631-046X)
- Hirokazu Takahashi (ORCID: https://orcid.org/0000-0002-2374-2889)
Institutions
- Saga University (JP)
- Kawasaki Medical School (JP)
- Kyoto Prefectural University of Medicine (JP)
- Nara City Hospital (JP)
- Saiseikai Suita Hospital (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Liver International
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1111/liv.16124
- Citations
- 12
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology