From Life’s Essential 8 to metabolic syndrome: insights from NHANES database and network pharmacology analysis of quercetin

This study discovered that an optimal LE8 score is a marker of adopting a lifestyle of wellness and is connected with a reduced likelihood of developing MetS. Quercetin acts on core targets such as IL6, BCL2, TP53, IL1B, MAPK1, and CCL2, and then plays a therapeutic role in regulating lipid metabolism, anti-inflammation, immunomodulation, autophagy, etc., through the pathways of diabetic complications, lipids, atherosclerosis, etc., and has the characteristics of multi-targets, multi-pathways, and multi-functions in regulating interventions for MetS.