EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma
Our findings highlight the functional dichotomy of the EZH2 CXC domain in governing ROS-stratified therapeutic resistance, thereby advocating for the development of therapeutic approaches targeting its noncanonical activities and underscoring the significance of patient stratification methodologies.
Authors
- Patrick Tan (ORCID: https://orcid.org/0000-0002-0179-8048)
- Beng Ti Ang (ORCID: https://orcid.org/0000-0001-7252-5146)
- Carol Tang (ORCID: https://orcid.org/0000-0002-1835-5083)
- Qing You Pang (ORCID: https://orcid.org/0000-0002-8988-7255)
- Wisna Novera
- Yuk Kien Chong
- Stephen Yip (ORCID: https://orcid.org/0000-0002-8514-9861)
- Gabriel Rosser (ORCID: https://orcid.org/0000-0001-9482-573X)
- Nguan Soon Tan (ORCID: https://orcid.org/0000-0003-0136-7341)
- Samantha Ya Lyn Ang
- David C.Y. Low
- Jianhong Ching (ORCID: https://orcid.org/0000-0003-1526-8459)
- Huilin Shao (ORCID: https://orcid.org/0000-0003-4513-1410)
- See Wee Lim
- Anne M. Phelan (ORCID: https://orcid.org/0000-0002-3926-2134)
- Lynnette Koh
- Yulan Wang (ORCID: https://orcid.org/0000-0002-2831-8737)
- Shang Li (ORCID: https://orcid.org/0000-0002-6226-3362)
- Jinyue Liu (ORCID: https://orcid.org/0000-0003-2094-6365)
- Ron Weng Yee Loh
Institutions
- Agency for Science, Technology and Research (SG)
- University of British Columbia (CA)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- National University Cancer Institute, Singapore (SG)
- KK Women's and Children's Hospital (SG)
- BenevolentAI (United Kingdom) (GB)
- National Neuroscience Institute (SG)
- Genome Institute of Singapore (SG)
- Institute of Molecular and Cell Biology (SG)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1093/neuonc/noae206
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Research Foundation Singapore