EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma

Our findings highlight the functional dichotomy of the EZH2 CXC domain in governing ROS-stratified therapeutic resistance, thereby advocating for the development of therapeutic approaches targeting its noncanonical activities and underscoring the significance of patient stratification methodologies.

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Publication Details

Journal
Neuro-Oncology
Published
2024-10-07
DOI
https://doi.org/10.1093/neuonc/noae206
Citations
4
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.94

Funders

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article

EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma

Patrick Tan, Beng Ti Ang, Carol Tang, Qing You Pang et al.
4 citations
Neuro-Oncology
Epigenetics and DNA Methylation
0.94
article

EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma

Patrick Tan, Beng Ti Ang, Carol Tang, Qing You Pang, Wisna Novera, Yuk Kien Chong, Stephen Yip, Gabriel Rosser, Nguan Soon Tan, Samantha Ya Lyn Ang, David C.Y. Low, Jianhong Ching, Huilin Shao, See Wee Lim, Anne M. Phelan, Lynnette Koh, Yulan Wang, Shang Li, Jinyue Liu, Ron Weng Yee Loh
article en
4 citations

Abstract

Our findings highlight the functional dichotomy of the EZH2 CXC domain in governing ROS-stratified therapeutic resistance, thereby advocating for the development of therapeutic approaches targeting its noncanonical activities and underscoring the significance of patient stratification methodologies.

Neuro-OncologyVol. 27(2)
Agency for Science, Technology and Research (SG), University of British Columbia (CA), National University of Singapore (SG), Nanyang Technological University (SG), SingHealth Duke-NUS Academic Medical Centre (SG), National University Cancer Institute, Singapore (SG), KK Women's and Children's Hospital (SG), BenevolentAI (United Kingdom) (GB), National Neuroscience Institute (SG), Genome Institute of Singapore (SG), Institute of Molecular and Cell Biology (SG)
National Research Foundation Singapore
Life in Land
Openalex Percentile: Top 25%
Epigenetics and DNA Methylation
0.94
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