The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States
SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentrations and decay rates estimated that one year after infection, participants would serorevert for anti-nucleocapsid antibodies and remain seropositive for anti-spike antibodies. The peak anti-spike concentrations were higher for individuals vaccinated prior to infection, but the decay rates were similar across immunologic status groups. Children had significantly lower peak anti-spike concentrations than adults. This study affirms the importance of continued vaccination to maintain high levels of immunity in the face of waning immunity.
Authors
- Oliver Laeyendecker (ORCID: https://orcid.org/0000-0002-6429-4760)
- Dennie Parker
- Owen R. Baker (ORCID: https://orcid.org/0009-0006-0728-6509)
- Rachel M. Hartman (ORCID: https://orcid.org/0000-0002-6837-4629)
- Claire M. Midgley (ORCID: https://orcid.org/0000-0001-5196-4713)
- Saki Takahashi (ORCID: https://orcid.org/0000-0001-5413-5507)
- Tarayn Fairlie (ORCID: https://orcid.org/0000-0001-9954-7185)
- Claire P. Smith (ORCID: https://orcid.org/0000-0003-1069-9460)
- Reinaldo E. Fernández (ORCID: https://orcid.org/0000-0002-7751-6422)
- Catherine G. Sutcliffe (ORCID: https://orcid.org/0000-0001-8512-8326)
- Laura L. Hammitt (ORCID: https://orcid.org/0000-0001-6051-1484)
- Elvira Honie
- Melissa B. Hagen
- Alexa M. Kugler
- Verlena Little
- Marqia Sandoval
Institutions
- Centers for Disease Control and Prevention (US)
- National Institutes of Health (US)
- Johns Hopkins University (US)
- National Center for Immunization and Respiratory Diseases (US)
- Johns Hopkins Medicine (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Viruses
- Published
- 2024-10-05
- DOI
- https://doi.org/10.3390/v16101573
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention