Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of pharmacokinetic properties prediction of ADME
The ADMEs are based on adsorption-desorption kinetics and pharmacopoeia. Adsorption and distribution analysis is used to assess the potential of a drug candidate. In vitro ADME is exploited to expect the effect of Pgp transport on the drug candidates. ADME has been used to predict CYP1A2 inhibitors and to predict PPB and BBB penetration. This work summarizes the current knowledge on molecular docking, ADME and identifies potential drug candidates for ADME in vitro and in vivo .
Authors
- Rehab M. Bagadood (ORCID: https://orcid.org/0000-0001-5873-4152)
- Banan Atwah (ORCID: https://orcid.org/0000-0001-9159-9781)
- Anmar A. Khan (ORCID: https://orcid.org/0000-0002-1463-8609)
- Mohammad A. Alobaidy (ORCID: https://orcid.org/0000-0002-6911-9179)
- Zain Alhindi (ORCID: https://orcid.org/0000-0003-3464-881X)
- Amna Moulana
- Ayman Qashgari
- Ghadir Sindi
- Afnan Shakoori (ORCID: https://orcid.org/0000-0002-3361-9243)
Institutions
- Umm al-Qura University (SA)
- Maternity and Children's Hospital (SA)
Publication Details
- Journal
- Journal of Vector Borne Diseases
- Published
- 2024-10-05
- DOI
- https://doi.org/10.4103/jvbd.jvbd_65_24
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00