Proximal Tubule Secretory Clearance, Injury, and Kidney Viability in Cirrhosis
Cirrhosis was characterized by molecular signs of tubular injury in stable outpatients without acute kidney injury, accompanied by largely preserved tubular secretory clearance and greater signs of tubular viability. Within the limitations of the study, this suggests a phenotype of chronic ischemic injury but with initial preservation of tubular function in cirrhosis.
Authors
- Scott W. Biggins (ORCID: https://orcid.org/0000-0002-3081-4668)
- Bryan Kestenbaum (ORCID: https://orcid.org/0000-0003-4799-5968)
- Andrew S. Allegretti (ORCID: https://orcid.org/0000-0001-9416-6623)
- Michael L. Granda (ORCID: https://orcid.org/0000-0001-6197-7702)
- Raimund Pichler (ORCID: https://orcid.org/0000-0002-7685-9415)
- Lena Sibulesky (ORCID: https://orcid.org/0000-0001-5435-737X)
- David K. Prince (ORCID: https://orcid.org/0000-0001-6761-5606)
- Eric Luitweiler
- Cary H. Paine (ORCID: https://orcid.org/0000-0002-4102-7969)
Institutions
- University of Pittsburgh (US)
- University of Washington (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.14309/ctg.0000000000000775
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00