Triazole-bridged peptides with enhanced antimicrobial activity and potency against pathogenic bacteria
combat resistant bacterial strains.A novel antimicrobial peptide, 8A, demonstrated potent antibacterial activity, stability against proteolytic cleavage, selectivity for bacteria over human cells, and potential cytotoxic effects against cancer cells, making it a promising candidate for further research.
Authors
- Ines Neundorf (ORCID: https://orcid.org/0000-0001-6450-3991)
- Jacob Mayer (ORCID: https://orcid.org/0000-0003-2598-7326)
- Anna Maria Papini (ORCID: https://orcid.org/0000-0002-2947-7107)
- Berenike Maier (ORCID: https://orcid.org/0000-0001-6971-9927)
- Denise Meinberger (ORCID: https://orcid.org/0000-0002-7786-6000)
- Isabelle Wielert (ORCID: https://orcid.org/0000-0002-7259-3883)
- Andreas R. Klatt (ORCID: https://orcid.org/0000-0002-8517-7512)
- Joshua Grabeck (ORCID: https://orcid.org/0000-0003-1126-1647)
- Michael Quagliata (ORCID: https://orcid.org/0000-0003-0891-3405)
- Michele Casoria (ORCID: https://orcid.org/0009-0007-2960-3971)
- Axel Mayer
Institutions
- TH Köln - University of Applied Sciences (DE)
- University of Cologne (DE)
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1092
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00