Greater Neuromuscular and Perceptual Fatigue after Low versus High Loads in the Bench Press: A Preliminary Study Applying Frequentist and Bayesian Group Analyses with Subject-by-Subject Case Series Reports

<b>Background/Objective:</b> This study investigated the differences in acute fatigue following resistance training performed with low versus high loads in the bench press (BP). <b>Methods:</b> Trained males (n = 5, 21.2 ± 2.77 years; 81.86 ± 6.67 kg; 177 ± 7.52 cm) undertook three protocols with 50%RM and three with 85%RM with volume equalized between protocols: muscular failure protocols (TF, RTP1 and 2), half-maximum repetition protocols (RTP3 and 4), and cluster set protocols (RTP5 and 6). Mechanical performance, lactate, and perceptual responses were analyzed during protocols and at post 0, 24, and 48 h using frequentist (<i>p</i> < 0.05) and Bayesian approaches. <b>Results:</b> Moderate to large (ES ≥ 0.3) and trivial to moderate (ES < 0.3) effects were observed at 0 and 24 h post-session, respectively, across all protocols. TF protocols, particularly RTP1, showed the greatest impairments when compared to the other RTP (ES ≥ 0.3). The Bayesian analysis supported the frequentist results, showing strong-decisive evidence for our data under the model that included protocols as predictors for mechanical, metabolic, and perceptual variables during protocols. Inter-individual variability in responses was observed in the neuromuscular tests, potentially related to the strength level and perceptual responses. <b>Conclusions:</b> In summary, TF generates greater fatigue, while reducing set volume to half of maximum repetitions or including intra-set rest that helps to mitigate fatigue symptoms.