<i>Aedes aegypti</i> adiponectin receptor-like protein signaling facilitates Zika virus infection

Arboviruses pose a significant threat to public health, with mosquitoes, especially <i>Aedes aegypti</i>, being a major vector for their transmission. Gaining insight into the complex interaction between mosquitoes and viruses is essential to build successful control strategies. In this study, we identified a novel pathway connecting the <i>A. aegypti</i> adiponectin receptor-like protein and its association with trypsin, key enzymes involved in blood digestion. Furthermore, we demonstrated the significance of signaling via the adiponectin receptor-like protein in virus infection within the mosquito. Together, our discoveries illuminate mosquito metabolic pathways essential in viral infection.