Bispecific DNA-Peptide Conjugates for Targeting Cancer Cells

CAGCTCGAGGTATTATTCGCmakes Cells of a given tissue express a unique "fingerprint" of surface receptors.By targeting two oncogenic receptors that are uniquely overexpressed in a cancer cell of interest and displaying their peptide ligands in the proper arrangement, it is possible to achieve high-avidity, highly selective binding to cancerous cells over surrounding healthy cells.Herein, we demonstrate that the programmable base-pairing interactions make DNA an ideal scaffold 1-3 to direct the presentation of peptide ligands binding pairs of receptors, such as the VEGFR/ v 3 integrin and the EGFR/MET pairs.Designing the probes Targeting VEGFR2- v 3