Extracellular vesicles in sepsis plasma mediate neuronal inflammation in the brain through miRNAs and innate immune signaling
Circulating plasma EVs in septic mice cause a microglial proinflammatory response in vitro and a brain innate immune response in vivo, some of which are in part mediated by TLR7 in vitro and MyD88 signaling in vivo. These findings highlight the importance of circulating EVs in brain inflammation during sepsis.
Authors
- Zhuofan Lei (ORCID: https://orcid.org/0000-0002-4207-2796)
- Fengqian Chen (ORCID: https://orcid.org/0000-0002-2330-6403)
- Wei Chao (ORCID: https://orcid.org/0000-0002-2505-1360)
- Brittney Williams (ORCID: https://orcid.org/0000-0001-5835-2365)
- Boyang Ren (ORCID: https://orcid.org/0000-0002-4157-5199)
- Steven M. Jay (ORCID: https://orcid.org/0000-0002-3827-5988)
- Kavitha Brunner
- Jing Zhu (ORCID: https://orcid.org/0000-0002-8014-2855)
- Junfang Wu (ORCID: https://orcid.org/0000-0003-3338-7291)
- Lin Zou (ORCID: https://orcid.org/0000-0003-0820-4246)
- Chanhee Park (ORCID: https://orcid.org/0000-0003-2262-8555)
- Huang Huang (ORCID: https://orcid.org/0000-0002-7858-7855)
- Yun Li (ORCID: https://orcid.org/0000-0003-2040-4451)
- Hui Li (ORCID: https://orcid.org/0000-0001-7849-9735)
- Junyun He (ORCID: https://orcid.org/0000-0003-4325-5655)
Institutions
- University of Maryland, Baltimore (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s12974-024-03250-0
- Citations
- 17
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke