rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model
The study confirms NP is a highly effective BMP-2 carrier, significantly improving bone union rates and new bone formation in nonunion fractures. The sustained release of BMP-2 from the hydrogel component reduced inflammatory responses and enhanced bone regeneration. NP can be a promising alternative to collagen-based BMP-2 delivery systems.
Authors
- Takahito Fujimori (ORCID: https://orcid.org/0000-0002-2758-7919)
- Takashi Kaito (ORCID: https://orcid.org/0000-0003-4882-2997)
- Masayuki Bun (ORCID: https://orcid.org/0000-0002-6081-7210)
- Takayuki Kitahara (ORCID: https://orcid.org/0009-0008-0521-7598)
- Seiji Okada (ORCID: https://orcid.org/0000-0003-3124-5206)
- Masato Ikuta (ORCID: https://orcid.org/0000-0002-8125-2132)
- Daisuke Tateiwa (ORCID: https://orcid.org/0000-0003-2597-9115)
- Masayuki Furuya (ORCID: https://orcid.org/0000-0002-1652-7216)
- Yuichiro Ukon (ORCID: https://orcid.org/0000-0002-0747-8854)
- Hiromasa Hirai (ORCID: https://orcid.org/0000-0002-7607-0975)
- Yuya Kanie (ORCID: https://orcid.org/0000-0001-5977-1959)
- Takuya Furuichi (ORCID: https://orcid.org/0009-0003-9781-9548)
Institutions
- Osaka Prefectural Medical Center (JP)
- Osaka City General Hospital (JP)
- Osaka Rosai Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fbioe.2024.1461260
- Citations
- 9
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.66
Funders
- Japan Society for the Promotion of Science