Beta-Lactam Antibiotic Exposure During Pediatric Extracorporeal Membrane Oxygenation: Retrospective Cohort Analysis of Drug Levels Using Standard Dosing, 2018–2020
In this retrospective cohort of pediatric ECMO cases, there is an associated risk of underexposure when prescribing conventional dosing of beta-lactams, which are likely associated with renal impairment and fluid overload. Prospective testing of therapeutic drug monitoring combined with pharmacokinetic/pharmacodynamic models should be tested as a risk-reduction strategy in this vulnerable population.
Authors
- Alice Marsaux
- Sylvain Renolleau (ORCID: https://orcid.org/0000-0002-0638-5613)
- Inès Gana (ORCID: https://orcid.org/0000-0003-3171-7373)
- Julie Toubiana (ORCID: https://orcid.org/0000-0001-9561-669X)
- Jérôme Rambaud (ORCID: https://orcid.org/0000-0001-5906-9107)
- Sihem Benaboud
- Mehdi Oualha (ORCID: https://orcid.org/0000-0002-0488-5948)
- Agathe Béranger (ORCID: https://orcid.org/0000-0002-9751-8249)
- Marion Grimaud
- Jean‐Marc Tréluyer (ORCID: https://orcid.org/0000-0002-2045-4742)
- Emmanuelle Bille (ORCID: https://orcid.org/0000-0001-9172-0510)
- Pierre-Louis Léger
- Matthie Lorrot
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Université Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1097/pcc.0000000000003605
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.34