Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy
This case series of DIAVIS T-cell therapy in PML provides first class IV evidence suggesting efficacy to reduce mortality and improve functional outcome. Further prospective studies are required to confirm these results.
Authors
- Thomas Skripuletz (ORCID: https://orcid.org/0000-0001-8550-335X)
- Dennis Holzwart
- Julian Zimmermann (ORCID: https://orcid.org/0000-0003-1964-0078)
- Nora Möhn
- Armin Koch
- Rainer Blasczyk (ORCID: https://orcid.org/0000-0003-3875-3190)
- Lilia Goudeva
- Franziska Hopfner (ORCID: https://orcid.org/0000-0001-6524-0281)
- Sandra Nay (ORCID: https://orcid.org/0000-0002-4986-1181)
- Britta Eiz‐Vesper (ORCID: https://orcid.org/0000-0001-8378-3298)
- Philipp Schwenkenbecher (ORCID: https://orcid.org/0000-0002-1260-1650)
- Kurt‐Wolfram Sühs (ORCID: https://orcid.org/0000-0002-8077-481X)
- Mike Peter Wattjes (ORCID: https://orcid.org/0000-0001-9298-2897)
- David Hagin (ORCID: https://orcid.org/0000-0003-2702-1031)
- Nima Mahmoudi (ORCID: https://orcid.org/0000-0002-2053-9623)
- Britta Maecker‐Kolhoff (ORCID: https://orcid.org/0000-0001-8164-514X)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Clemens Warnke (ORCID: https://orcid.org/0000-0002-3510-9255)
- Lea Grote‐Levi
- Agnes Bonifacius (ORCID: https://orcid.org/0000-0002-0112-967X)
- Mieke Luise Saßmann
- Sabine Tischer‐Zimmermann (ORCID: https://orcid.org/0009-0000-9724-3751)
Institutions
- University of Cologne (DE)
- University Hospital Bonn (DE)
- Tel Aviv Sourasky Medical Center (IL)
- German Center for Neurodegenerative Diseases (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- Munich Cluster for Systems Neurology (DE)
- German Center for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- University Hospital Cologne (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1001/jamaneurol.2024.3324
- Citations
- 23
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.50
Funders
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Alnylam Pharmaceuticals
- Celgene
- Hexal AG
- CSL Behring
- Les Laboratories Pierre Fabre
- Argenx
- Deutsche Forschungsgemeinschaft
- Swedish Orphan Biovitrum
- Grifols
- Bayer Vital
- Cilag