Circulating Tumor Cell Count and Overall Survival in Patients With Metastatic Hormone-Sensitive Prostate Cancer
In this prognostic study, the findings validate CTC count as a prognostic biomarker that improved upon existing prognostic factors and estimated vastly divergent survival outcomes regardless of subsequent lines of therapy. As such, baseline CTC count in mHSPC may serve as a valuable noninvasive biomarker to identify men likely to have poor survival who may benefit from clinical trials of intensified or novel regimens.
Authors
- Ian M. Thompson (ORCID: https://orcid.org/0000-0003-0833-952X)
- Timothy J. Triche (ORCID: https://orcid.org/0000-0003-4869-8826)
- Catherine M. Tangen (ORCID: https://orcid.org/0000-0001-8825-8660)
- Daniel Bsteh (ORCID: https://orcid.org/0000-0002-0405-0641)
- David I. Quinn (ORCID: https://orcid.org/0000-0002-1411-0417)
- Melissa Plets (ORCID: https://orcid.org/0009-0005-1449-0674)
- Maha Hussain (ORCID: https://orcid.org/0000-0003-0380-9465)
- Daniel A. Vaena (ORCID: https://orcid.org/0000-0001-5389-9193)
- Seth P. Lerner (ORCID: https://orcid.org/0000-0002-6379-2581)
- Amir Goldkorn (ORCID: https://orcid.org/0000-0003-4664-9166)
- David J. McConkey (ORCID: https://orcid.org/0000-0003-1971-0638)
- Gary R. MacVicar
- Sue A. Ingles (ORCID: https://orcid.org/0000-0001-9181-8745)
- Primo N. Lara (ORCID: https://orcid.org/0000-0001-9512-0002)
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- Neeraj Agarwal (ORCID: https://orcid.org/0000-0003-1076-0428)
- Tong Xu
- Jacek Pinski
- Anthony W. Crispino
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- Baylor College of Medicine (US)
- University of Utah (US)
- Keck Hospital of USC (US)
- Huntsman Cancer Institute (US)
- Christus Health (US)
- Fred Hutch Cancer Center (US)
- City of Hope (US)
- USC Norris Comprehensive Cancer Center (US)
- Las Vegas Institute (US)
- Illinois CancerCare (US)
- University of Iowa Health Care (US)
- UC Davis Comprehensive Cancer Center
- University of California, Davis (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.37871
- Citations
- 28
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 11.73