Dimerization and lysine substitution of melittin have differing effects on bacteria
Dimerization and Lys substitution of melittin improved the antimicrobial activity toward Gram-negative bacteria but did not significantly improve its activity toward Gram-positive bacteria. Some analogs also displayed reduced toxicity toward HEK293 and H4IIE cells but overall remained toxic at bactericidal concentrations. Our data indicates that although highly antibacterial, melittin's toxicity is the major drawback in its potential use.
Authors
- Jason C. Lenzo (ORCID: https://orcid.org/0000-0002-0564-9250)
- Neil M. O’Brien‐Simpson (ORCID: https://orcid.org/0000-0001-8462-5603)
- Tamara Matthyssen (ORCID: https://orcid.org/0000-0003-0053-7679)
- Sara Hadjigol (ORCID: https://orcid.org/0000-0002-2342-7205)
- Wenyi Li (ORCID: https://orcid.org/0000-0003-3584-0301)
- James A. Holden (ORCID: https://orcid.org/0000-0001-6543-5281)
Institutions
- The University of Melbourne (AU)
- La Trobe University (AU)
- Harry Perkins Institute of Medical Research (AU)
- Royal Dental Hospital of Melbourne (AU)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fphar.2024.1443497
- Citations
- 4
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.38
Funders
- University of Melbourne
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Cancer Council Victoria