Ameliorative effects of Penthorum chinense Pursh on insulin resistance and oxidative stress in diabetic obesity db/db mice
PCP significantly alleviated hyperglycemia, hyperinsulinemia, hyperlipidemia, and obesity, inhibited hepatic oxidative stress, and enhanced hepatic glucose transport in T2DM mice. Based on the above findings, the hypoglycemic effect of PCP may be attributed to the activation of the GLUT2/GCK expression in the liver and the reduction of hepatic oxidative stress.
Authors
- Leyu Zheng
- Jilei Hu (ORCID: https://orcid.org/0000-0002-2706-0535)
- Ning Lin (ORCID: https://orcid.org/0000-0001-6374-8823)
- Huibo Xie
- Hongmei Lang (ORCID: https://orcid.org/0000-0002-1862-1396)
- Xi Fan (ORCID: https://orcid.org/0009-0009-4179-0161)
Institutions
- Southwest Medical University (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1371/journal.pone.0311502
- Citations
- 3
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Sichuan Education and Scientific Research Grant Project