Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis

Overall, by employing a multiomic approach, this study provides the first comprehensive map of the cellular and transcriptomic diversity of human IFP and identifies IFP fibroblasts as key cells contributing to transcriptomic and metabolic differences related to KOA disease, sex or obesity.

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Publication Details

Journal
Annals of the Rheumatic Diseases
Published
2024-10-07
DOI
https://doi.org/10.1136/ard-2024-225928
Citations
27
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
12.69

Funders

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article

Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis

Noah Fine, Shabana Vohra, Keemo Delos Santos, Yoga Raja Rampersaud et al.
27 citations
Annals of the Rheumatic Diseases
Osteoarthritis Treatment and Mechanisms
12.69
article

Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis

Noah Fine, Shabana Vohra, Keemo Delos Santos, Yoga Raja Rampersaud, Teodora Tockovska, Nikita Looby, K. Perry, Anthony V. Perruccio, Katrina Hueniken, Nizar N. Mahomed, Igor Jurišica, Hayley Peters, Sheng Han Li, Vinod Chandran, Pratibha Potla, Matthew B. Buechler, Starlee Lively, Roman Krawetz, Eric Gracey, Chiara Pastrello, Mohit Kapoor, Rajiv Gandhi, Khalid Syed, Jason S. Rockel, Paramvir Kaur
article en
27 citations

Abstract

Overall, by employing a multiomic approach, this study provides the first comprehensive map of the cellular and transcriptomic diversity of human IFP and identifies IFP fibroblasts as key cells contributing to transcriptomic and metabolic differences related to KOA disease, sex or obesity.

Annals of the Rheumatic DiseasesVol. 84(2)
University Health Network (CA), University of Calgary (CA), University of Toronto (CA), Ghent University Hospital (BE), Princess Margaret Cancer Centre (CA), Ghent University (BE), Arthritis Society (CA), Alberta Bone and Joint Health Institute (CA), Public Health Ontario (CA), VIB-UGent Center for Inflammation Research (BE), Krembil Research Institute
Canada Foundation for Innovation, Canada Research Chairs
Good health and well-being
Openalex Percentile: Top 1%
Osteoarthritis Treatment and Mechanisms
12.69
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