Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis
Overall, by employing a multiomic approach, this study provides the first comprehensive map of the cellular and transcriptomic diversity of human IFP and identifies IFP fibroblasts as key cells contributing to transcriptomic and metabolic differences related to KOA disease, sex or obesity.
Authors
- Noah Fine (ORCID: https://orcid.org/0000-0002-7234-094X)
- Shabana Vohra (ORCID: https://orcid.org/0000-0003-1995-3795)
- Keemo Delos Santos
- Yoga Raja Rampersaud (ORCID: https://orcid.org/0000-0002-2521-5900)
- Teodora Tockovska
- Nikita Looby (ORCID: https://orcid.org/0000-0003-4141-9070)
- K. Perry
- Anthony V. Perruccio (ORCID: https://orcid.org/0000-0002-4389-0993)
- Katrina Hueniken (ORCID: https://orcid.org/0000-0003-1376-8046)
- Nizar N. Mahomed (ORCID: https://orcid.org/0000-0002-6907-1750)
- Igor Jurišica (ORCID: https://orcid.org/0000-0002-2507-946X)
- Hayley Peters
- Sheng Han Li
- Vinod Chandran (ORCID: https://orcid.org/0000-0002-8297-0275)
- Pratibha Potla (ORCID: https://orcid.org/0000-0002-3000-6820)
- Matthew B. Buechler (ORCID: https://orcid.org/0000-0003-1902-622X)
- Starlee Lively (ORCID: https://orcid.org/0000-0003-0655-535X)
- Roman Krawetz (ORCID: https://orcid.org/0000-0002-2576-4504)
- Eric Gracey (ORCID: https://orcid.org/0000-0003-0984-435X)
- Chiara Pastrello (ORCID: https://orcid.org/0000-0002-1934-7472)
- Mohit Kapoor (ORCID: https://orcid.org/0000-0001-9877-0772)
- Rajiv Gandhi (ORCID: https://orcid.org/0000-0002-3332-527X)
- Khalid Syed (ORCID: https://orcid.org/0000-0001-7806-3464)
- Jason S. Rockel
- Paramvir Kaur
Institutions
- University Health Network (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Ghent University Hospital (BE)
- Princess Margaret Cancer Centre (CA)
- Ghent University (BE)
- Arthritis Society (CA)
- Alberta Bone and Joint Health Institute (CA)
- Public Health Ontario (CA)
- VIB-UGent Center for Inflammation Research (BE)
- Krembil Research Institute
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1136/ard-2024-225928
- Citations
- 27
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 12.69
Funders
- Canada Foundation for Innovation
- Canada Research Chairs