A new algorithm for coeliac disease based on the ‘long forgotten’ TCRγδ<sup>+</sup> intra‐epithelial lymphocytes detected with an antibody working on FFPE sections
The new antibody detecting γδ<sup>+</sup> IELs in FFPE sections revealed thresholds of 10.5 for γδ<sup>+</sup> IELs and 14% for γδ<sup>+</sup>/CD3<sup>+</sup>IEL ratio which distinguished coeliacs from non-coeliacs with high sensitivity and specificity, particularly in cases with normal villus/crypt axis including type 1 CD, non-CD IELosis and controls. A 'coeliac algorithm' based on γδ<sup>+</sup> IELs is proposed with the hope that it will be used in the histopathological diagnostic approach by the pathology community.
Authors
- Derya Öztuna (ORCID: https://orcid.org/0000-0001-6266-3035)
- Berna Savaş (ORCID: https://orcid.org/0000-0003-3971-1419)
- Eda Nur Kozan (ORCID: https://orcid.org/0000-0001-8363-5068)
- Ayça Kırmızı (ORCID: https://orcid.org/0000-0003-3192-1921)
- Arzu Ensarı (ORCID: https://orcid.org/0000-0001-7036-4457)
- Ceyda Tuna Kırşaçlıoğlu (ORCID: https://orcid.org/0000-0002-3551-7267)
- Aydan Kansu (ORCID: https://orcid.org/0000-0002-3133-9846)
- Arif I Soykan
Institutions
- Ankara University (TR)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Histopathology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1111/his.15330
- Citations
- 5
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Ankara Universitesi