The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
Authors
- Erin Yamamoto (ORCID: https://orcid.org/0000-0001-5517-1438)
- Olabisi Sanusi (ORCID: https://orcid.org/0000-0002-2467-2739)
- Juan Piantino (ORCID: https://orcid.org/0000-0002-8861-5709)
- Ahmet Baki Dogan (ORCID: https://orcid.org/0000-0002-4113-1619)
- Jesse Liu (ORCID: https://orcid.org/0000-0001-5819-7860)
- Jacob H. Bagley
- Mathew Geltzeiler (ORCID: https://orcid.org/0000-0001-6553-3885)
Institutions
- Oregon Health & Science University (US)
- Aurora St. Luke's Medical Center (US)
- Doernbecher Children's Hospital (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1073/pnas.2407246121
- Citations
- 43
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 11.54
Funders
- National Heart, Lung, and Blood Institute