White Matter Hyperintensities and Cognitive Functions in People With the R544C Variant of the <i>NOTCH3</i> Gene Without Stroke or Dementia
Our study revealed that WMHs are extensively distributed in R544C carriers WOCD. They exhibited a rapid increase in WMHs beginning at age 48, approximately 7 years earlier than the reported age at symptomatic onset. Age was the strongest predictive factor of WMHs, and VRF, particularly hypercholesterolemia, might be modifying factors of WMHs.
Authors
- Shuchun Chen (ORCID: https://orcid.org/0000-0003-1201-8198)
- Jyh‐Wen Chai
- Hsin Tung (ORCID: https://orcid.org/0000-0003-4224-3054)
- Chien‐Chih Chou (ORCID: https://orcid.org/0000-0003-3332-0900)
- Yi‐Ming Chen (ORCID: https://orcid.org/0000-0001-7593-3065)
- Y. Wu (ORCID: https://orcid.org/0000-0003-1878-1901)
- Hung-Chieh Chen
- Hsian-Min Chen
- Jun-Peng Chen
- Wei‐Ju Lee (ORCID: https://orcid.org/0000-0002-3720-4539)
Institutions
- Taichung Veterans General Hospital (TW)
Publication Details
- Journal
- Neurology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1212/wnl.0000000000209941
- Citations
- 4
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.48