Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway
These results have revealed an additional mechanism by which senescent cells promote tumor cell metastasis and tumor progression, and will potentially lead to identification of novel targets for cancer therapies that suppress metastasis, the major cause of cancer mortality.
Authors
- Hong Liu (ORCID: https://orcid.org/0000-0001-8557-9549)
- Yigong Hou
- Shuang Yang (ORCID: https://orcid.org/0000-0002-4779-8553)
- Dongmei Cheng (ORCID: https://orcid.org/0000-0002-4638-0884)
- Emily V. Dressler (ORCID: https://orcid.org/0000-0002-6054-7839)
- Nan Wang (ORCID: https://orcid.org/0000-0003-1520-4375)
- Juan Wang (ORCID: https://orcid.org/0000-0002-3176-173X)
- Peiqing Sun
- Rong Xiang (ORCID: https://orcid.org/0000-0003-0651-5446)
- Yan Fang (ORCID: https://orcid.org/0000-0003-1275-8276)
- Guanwen Wang (ORCID: https://orcid.org/0000-0001-7026-5854)
- Yilei Li
- Hao Wang (ORCID: https://orcid.org/0000-0001-5461-0689)
Institutions
- Hebei Agricultural University (CN)
- Jiangnan University (CN)
- Atrium Health Wake Forest Baptist (US)
- Memorial Sloan Kettering Cancer Center (US)
- Chongqing University (CN)
- Nankai University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Nanfang Hospital (CN)
- Chongqing Cancer Hospital (CN)
- Wake Forest Baptist Comprehensive Cancer Center
- Southern Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s12964-024-01861-x
- Citations
- 7
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- China Scholarship Council
- National Institutes of Health
- National Cancer Institute