Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment
Our research results demonstrate the excellent tumor-targeting effect of PG/ICG@MPs. By modulating arginine metabolism to improve the tumor immune microenvironment, we provide an effective approach with clinical translational significance for combined cancer therapy.
Authors
- Kailin Cai
- Yinghao Cao (ORCID: https://orcid.org/0000-0001-8221-7251)
- Fuwei Mao
- Le Qin (ORCID: https://orcid.org/0000-0003-3100-0364)
- Yifan Xue (ORCID: https://orcid.org/0000-0003-4068-2707)
- Mian Chen (ORCID: https://orcid.org/0000-0003-2342-4861)
- Shenghe Deng (ORCID: https://orcid.org/0000-0001-6184-1389)
- Junnan Gu (ORCID: https://orcid.org/0000-0003-4828-6514)
- Ning Huang (ORCID: https://orcid.org/0000-0002-0928-0091)
- Denglong Cheng
- Zhenxin Jiang
- Falong Zou (ORCID: https://orcid.org/0009-0007-7189-6077)
- Jun Wang (ORCID: https://orcid.org/0000-0002-6278-0677)
Institutions
- Union Hospital (HK)
- National University of Singapore (SG)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Clinical Nutrition Research Centre (SG)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s12967-024-05652-3
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation