Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study
Results revealed activation of genes associated with biological aging in women with breast cancer from diagnosis through early survivorship, including DNA damage response, cell senescence, and the inflammatory secretome. Increases were evident across cancer treatments, although women receiving CT showed sustained increases, whereas RT exhibited slowing at later time points. Overall, findings suggest that women treated for breast cancer are aging within their immune cells.
Authors
- Judith Carroll (ORCID: https://orcid.org/0000-0001-5516-0819)
- Catherine M. Crespi (ORCID: https://orcid.org/0000-0002-6150-2181)
- Laura Petersen (ORCID: https://orcid.org/0000-0002-4843-2692)
- Steve Cole
- Peter Ganz (ORCID: https://orcid.org/0000-0002-0437-8882)
- Julienne E. Bower (ORCID: https://orcid.org/0000-0003-0813-4444)
Institutions
- Salk Institute for Biological Studies (US)
- University of California, Los Angeles (US)
- UCLA Health (US)
- Neurobehavioral Systems (US)
- UCLA Jonsson Comprehensive Cancer Center
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1093/jnci/djae201
- Citations
- 9
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Cancer Institute