Computational Modelling of the Impact of Evaporation on In-Vitro Dermal Absorption
The evaporation of volatile permeants under finite dose in vitro permeation test conditions has been successfully predicted using a mechanistic model with the intrinsic volatility parameter vapour pressure. Integrating evaporation in PBPK modelling significantly improved the prediction of dermal delivery.
Authors
- Benjamin N. Deacon (ORCID: https://orcid.org/0000-0002-9161-730X)
- Samadhi Silva (ORCID: https://orcid.org/0009-0009-0762-1751)
- Marina V. Evans (ORCID: https://orcid.org/0000-0002-2479-1738)
- Tao Chen (ORCID: https://orcid.org/0000-0002-3941-1603)
- Guoping Lian (ORCID: https://orcid.org/0000-0002-2499-2353)
Institutions
- Environmental Protection Agency (US)
- Unilever (United Kingdom) (GB)
- University of Surrey (GB)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1007/s11095-024-03779-y
- Citations
- 6
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- U.S. Environmental Protection Agency
- University of South Australia
- Biotechnology and Biological Sciences Research Council