Evaluation of different standard and modified two-tier testing strategies for the laboratory diagnosis of lyme borreliosis in a European setting
In conclusion, MTTT strategies showed a slightly higher sensitivity and similar specificity compared to STTT strategies. Since EIAs are more time- and cost-efficient, MTTT strategies seem more favorable for clinical use. IgG testing enhances specificity with minimal sensitivity loss.
Authors
- Karen Kerkhof (ORCID: https://orcid.org/0000-0002-2208-9902)
- Michiel Heron (ORCID: https://orcid.org/0000-0003-0576-8652)
- Steven Thijsen (ORCID: https://orcid.org/0009-0000-8411-1653)
- Tamara van Gorkom (ORCID: https://orcid.org/0000-0002-1565-5902)
- B. J. A. Hoeve-Bakker (ORCID: https://orcid.org/0000-0002-3872-3437)
Institutions
- Erasmus MC (NL)
- National Institute for Public Health and the Environment (NL)
- Diakonessenhuis hospital (NL)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1007/s10096-024-04956-y
- Citations
- 6
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.09