Dose-escalated Adaptive Radiotherapy for Bladder Cancer: Results of the Phase 2 RAIDER Randomised Controlled Trial
Grade ≥3 late toxicity was low. DART was safe and feasible to deliver, meeting preset toxicity thresholds. Disease-related outcomes are promising for dose-escalated treatments, with a low salvage cystectomy rate and overall survival similar to that seen in cystectomy cohorts.
Authors
- Ashok Nikapota (ORCID: https://orcid.org/0000-0002-0166-7734)
- Duncan B. McLaren (ORCID: https://orcid.org/0000-0002-9862-4158)
- Amanda Webster (ORCID: https://orcid.org/0000-0003-3416-8576)
- K. Warren-Oseni
- Colin Tang (ORCID: https://orcid.org/0000-0002-4643-0466)
- H. Gribble
- Ben Hindson
- Clare Griffin (ORCID: https://orcid.org/0000-0002-0127-4201)
- Farshad Foroudi (ORCID: https://orcid.org/0000-0001-8387-0965)
- S. Hafeez (ORCID: https://orcid.org/0000-0002-2057-0946)
- H. McNair (ORCID: https://orcid.org/0000-0001-7389-5587)
- Tomas Kron (ORCID: https://orcid.org/0000-0002-5189-4046)
- Ananya Choudhury (ORCID: https://orcid.org/0000-0002-3561-6580)
- Robert Anthony Huddart (ORCID: https://orcid.org/0000-0003-3604-1990)
- C. Vassallo-Bonner
- Courtney Hill
- Omi Parikh (ORCID: https://orcid.org/0000-0003-4181-7124)
- Emma Patel
- Rebecca Lewis (ORCID: https://orcid.org/0000-0001-9222-5263)
- L. Philipps (ORCID: https://orcid.org/0000-0002-3736-9798)
- Alison Birtle (ORCID: https://orcid.org/0000-0002-2621-0909)
- Isabel Syndikus (ORCID: https://orcid.org/0000-0001-5781-2067)
- Ka Ching Cheung
- Ann Henry (ORCID: https://orcid.org/0000-0002-5379-6618)
- Emma Hall (ORCID: https://orcid.org/0009-0002-0026-974X)
- Elizabeth Miles (ORCID: https://orcid.org/0000-0002-0645-4703)
- Mohini Varughese
Institutions
- University College Hospital (GB)
- Lancashire Teaching Hospitals NHS Foundation Trust (GB)
- NHS Lothian (GB)
- Royal Marsden NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Western General Hospital (GB)
- Royal Sussex County Hospital (GB)
- Peter MacCallum Cancer Centre (AU)
- Royal Devon and Exeter Hospital (GB)
- Sir Charles Gairdner Hospital (AU)
- Christchurch Hospital (NZ)
- Clatterbridge Cancer Centre NHS Foundation Trust (GB)
- Trans Tasman Radiation Oncology Group (AU)
- The Christie NHS Foundation Trust (GB)
- Royal Preston Hospital (GB)
- Mount Vernon Hospital (GB)
- Austin Health (AU)
- University College London (GB)
Publication Details
- Journal
- European Urology
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1016/j.eururo.2024.09.006
- Citations
- 18
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.31
Funders
- Royal Marsden NHS Foundation Trust
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- Cancer Australia
- Cancer Society of New Zealand
- Manchester Biomedical Research Centre