The First Decade of SuFEx Chemistry: Advancements in SuFEx Polymerization, Non-Canonical SuFEx Reactions, and SuFEx Radiochemistry

Abstract This year marks the 10th anniversary of SuFEx chemistry, a field that has witnessed significant advancements over the past decade. These include efficient synthetic strategies toward polymerization via the SuFEx approach leading to diverse polymers, alongside the discovery of new SuFExable hubs and coupling conditions. Non-canonical reactions, such as deoxyfluorination and on-water reactions, have also emerged. Furthermore, there have been substantial strides in the radiosynthesis of [18F] SuFExable hubs. This review provides an overview of these developments, focusing on polymerization, non-canonical reaction, and radiochemistry in SuFEx chemistry. 1 Introduction 2 SuFEx Polymerization 3 Non-Canonical SuFEx Reactions 4 Fluorine-18 SuFEx Radiochemistry 5 Conclusions and Outlook