Stretchable wireless optoelectronic synergistic patches for effective wound healing
Physiotherapies play a crucial role in noninvasive tissue engineering for wound healing. However, challenges such as the implementation of complex interventions and unsatisfactory treatment outcomes impede widespread application. Here, we proposed a stretchable and wirelessly-powered optoelectronic synergistic patch with a dual-layer serpentine wireless receiver circuit to drive the optoelectronic modulation component. Optimized structure and impedance matching enable the patch to seamlessly attach to irregular skin surfaces and operate robustly over a 30% tensile strain range. Based on Sprague-Dawley rat wound model. The wound closure rate of the optoelectronic synergistic group significantly outperformed both monointervention and blank control groups. Mechanistically, optoelectronic synergistic intervention enhances the secretion of vascular endothelial marker proteins and growth factors, and stabilizes mitochondrial function during oxidative stress. Overall, the scalable amalgamation of flexible electronics, wireless transmission, and synergistic interventions promise to improve wound care.
Authors
- Youxin Chen (ORCID: https://orcid.org/0000-0002-7231-5058)
- Wenhao Lou (ORCID: https://orcid.org/0000-0003-1246-899X)
- Zhen Cai
- Chenzheng Zhou (ORCID: https://orcid.org/0000-0002-9767-9448)
- Siyuan Cai
- Kangning Zhao (ORCID: https://orcid.org/0000-0003-2916-4386)
- Maowen Xie
- Taisong Pan (ORCID: https://orcid.org/0000-0003-1576-3409)
- Guang Yao (ORCID: https://orcid.org/0000-0002-6662-2422)
- Min Gao (ORCID: https://orcid.org/0000-0002-5075-0278)
- Liyuan Zhang (ORCID: https://orcid.org/0000-0002-7585-5607)
- Qian Wang (ORCID: https://orcid.org/0000-0002-8196-8026)
- Qingqing Li (ORCID: https://orcid.org/0000-0001-8940-4316)
- Yuan Lin (ORCID: https://orcid.org/0000-0002-9879-4341)
- Xingyi Gan
Institutions
- University of Electronic Science and Technology of China (CN)
- Army Medical University (CN)
- Wuhan University of Technology (CN)
- Xinqiao Hospital (CN)
- National Engineering Research Center of Electromagnetic Radiation Control Materials (CN)
Publication Details
- Journal
- npj Flexible Electronics
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1038/s41528-024-00351-x
- Citations
- 9
- Primary Topic
- Advanced Sensor and Energy Harvesting Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.66
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- University of Electronic Science and Technology of China
- Fundamental Research Funds for the Central Universities