Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy
The irradiated tumor itself represents an opportunity to establish endogenous in situ vaccines. However, such in situ cancer vaccination (ISCV) triggered by radiation therapy (RT) alone is very weak and hardly elicits systemic anticancer immunity. In this study, we develop two-dimensional risedronate-manganese nanobelts (RMn-NBs) as an adjuvant for RT to address this issue. RMn-NBs exhibit good T<sub>2</sub> magnetic resonance imaging performance and enhanced Fenton-like catalytic activity, which induces immunogenic cell death. RMn-NBs can inhibit the HIF-1α/VEGF axis to empower RT and synchronously activate the cGAS/STING pathway for promoting the secretion of type I interferon, thereby boosting RT-triggered ISCV and immune checkpoint blockade therapy against primary and metastatic tumors. RMn-NBs as a nano-adjuvant for RT show good biocompatibility and therapeutic efficacy, presenting a promising prospect for cancer radiotherapy and immunotherapy.
Authors
- Simin Song (ORCID: https://orcid.org/0009-0008-5491-8083)
- Lianhui Wang (ORCID: https://orcid.org/0000-0001-9030-9172)
- Shaoyin Zhang (ORCID: https://orcid.org/0009-0007-8951-8015)
- Yiqiao Hu (ORCID: https://orcid.org/0000-0002-3656-7143)
- Lixing Weng (ORCID: https://orcid.org/0000-0002-7719-892X)
- Yankui Ding
- Ahu Yuan (ORCID: https://orcid.org/0000-0003-3087-7367)
- Zhusheng Huang (ORCID: https://orcid.org/0000-0002-0676-9799)
- Yunlu Dai (ORCID: https://orcid.org/0000-0003-4023-7320)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-1116-2182)
- Zhimin Luo (ORCID: https://orcid.org/0000-0003-0851-2265)
- Shiqian Huang (ORCID: https://orcid.org/0000-0003-3066-8864)
- Hao Zhou
Institutions
- China Pharmaceutical University (CN)
- University of Macau (MO)
- Nanjing University of Posts and Telecommunications (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1038/s41467-024-53084-w
- Citations
- 37
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 6.82
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Universidade de Macau
- Nanjing University of Posts and Telecommunications
- Nanjing University
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund